Inflammation and Coronary Heart Disease

Inflammation is frequently in the news, tied to numerous diseases and specifically to coronary artery disease, especially after a meta-analysis published recently in the Lancet  (http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2812%2960110-X/abstract) which looked specifically at a genetic marker to reveal a causal relationship between inflammation and cardiovascular disease. The analysis of the 82 studies (nearly 135,000 patients) showed a causal relationship between the inflammatory marker and coronary heart disease.

For interesting related information related to the pathology of inflammation in atherosclerosis, see Richard J. Frink’s 2002 textbook which shows full color gross and microscopic changes in the coronary arteries of patients with and without clinical coronary disease (Available from: http://www.ncbi.nlm.nih.gov/books/NBK2025/). Dr. Frink, now retired, has been a frequent contributor to the Journal of Invasive Cardiology over the years on this topic and it is exciting to see his work validated by the large meta analysis.

assay

 

 

Related citations:

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
IL6R Genetics Consortium Emerging Risk Factors Collaboration‡ <http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2961931-4/abstract#fn1>

Inflammatory Atherosclerosis: Characteristics of the Injurious Agent
Richard J Frink, MD, 2002, Sacramento, California, Heart Research Foundation of Sacramento

Gender Gap, Inflammation and Acute Coronary Disease: Are Women Resistant to Atheroma Growth? Observations at Autopsy
Richard J. Frink, MD
http://www.invasivecardiology.com/articles/Gender-Gap-Inflammation-and-Acute-Coronary-Disease-Are-Women-Resistant-Atheroma-Growth-Obse

Parallel Cholesterol Crystals: A Sign of Impending Plaque Rupture?
Richard J. Frink, MD
http://www.invasivecardiology.com/articles/Parallel-Cholesterol-Crystals-A-Sign-Impending-Plaque-Rupture

Assessment of Inflammatory Response to Transfemoral Transcatheter Aortic Valve Implantation Compared to Transapical and Surgical Procedures: A Pilot Study
Barbara E. Stähli, MD, Jürg Grünenfelder, MD, Stephan Jacobs, MD, Volkmar Falk, MD, Ulf Landmesser, MD, Manfred B. Wischnewsky, PhD, Thomas F. Lüscher, MD, Roberto Corti, MD, Willibald Maier, MD, Lukas A. Altwegg, MD
http://www.invasivecardiology.com/articles/assessment-inflammatory-response-transfemoral-transcatheter-aortic-valve-implantation-compa

Initial Results of Inflammatory Response, Matrix Remodeling, and Reactive Oxygen Species Following PCI in Acute Ischemic Myocardial Injury in Man
Erik Hedström, MD, PhD, Karin Åström-Olsson, MD, PhD, Ann-Kristin Öhlin, MD, PhD, Hans Öhlin, MD, PhD, Håkan Arheden, MD, PhD
http://www.invasivecardiology.com/articles/initial-results-inflammatory-response-matrix-remodeling-and-reactive-oxygen-species-followi

Preprocedural Inflammation Does Not Affect Neointimal Hyperplasia following Everolimus-Eluting Stent Implantation
Daisaku Nakatani, MD, PhD, Junya Ako, MD, PhD, Masao Yamasaki, MD, PhD, Takao Shimohama, MD, PhD, Takao Hasegawa, MD, Hiromasa Otake, MD, PhD, Katsuhisa Waseda, MD, PhD, Ichizo Tsujino, MD, PhD, Ryota Sakurai, MD, Bon-Kwon Koo, MD, PhD, Hyeonsoo Chang, MSME, Paul G. Yock, MD,  Krishnankutty Sudhir, MD, PhD, Wesley Pierson, PhD, §Gregg W. Stone, MD, Shigeru Saito, MD, Yasuhiro Honda, MD, Peter J. Fitzgerald, MD, PhD
http://www.invasivecardiology.com/articles/Preprocedural-Inflammation-Does-Not-Affect-Neointimal-Hyperplasia-following-Everolimus-Elut

Thrombosis, Inflammation, and Our Evolving Understanding of Vascular Biology during Interventional Therapy
John J. Young, MD
http://www.invasivecardiology.com/article/5057

Eptifibatide in Peripheral Vascular Interventions: Results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions
Nicolas W. Shammas, MD,  Eric J. Dippel, MD,  Jon H. Lemke, MD,  Jon Robken, MD,
H. Lester Kirchner, MD,  Vickie Takes, RTR,  Matthew J. Kapalis, BS,  Theresa Palabrica, MD
http://www.invasivecardiology.com/article/5055

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